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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Nobiletin, Sorafenib
Phytochemical Name Nobiletin (PubChem CID: 72344 )
Anticancer drug Name Sorafenib (PubChem CID: 216239 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 642
Ref_1
Pair Name Nobiletin, Sorafenib
Disease Info [ICD-11: 2C82] Prostate cancer Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation Up-regulation Expression BAX hsa581
Up-regulation Expression CDKN1A hsa1026
Up-regulation Expression RB1 hsa5925
In Vitro Model PC-3 Prostate carcinoma Homo sapiens (Human) CVCL_0035
Result NOB and SOR combination was more effective than SOR and NOB alone and reduced the exposure time for SOR and NOB in PC-3 cells. Combination strategy is a therapeutic potential to improve efficacy and reduce side-effect of SOR for the treatment of metastatic prostate cancer cells.
03. Reference
No. Title Href
1 Synergistic Effects of Nobiletin and Sorafenib Combination on Metastatic Prostate Cancer Cells. Nutr Cancer. 2019;71(8):1299-1312. doi: 10.1080/01635581.2019.1601237. Click
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